Peer-Reviewed Publications

Traa A, Soo SK, AlOkDa A, Ko B, Rocheleau CE and Van Raamsdonk JM (2023) Endosomal trafficking protein TBC-2 modulates stress resistance and lifespan through DAF-16-dependent and independent mechanisms. Aging Cell 00: e13762.

Meraş İ, Chotard L, Liontis T, Ratemi Z, Wiles B, Seo JH, Van Raamsdonk JM and Rocheleau CE (2022) The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan. PLoS Genetics 18(8): e1010328.

Gauthier KD and Rocheleau CE (2021) LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.  Molecular Biology of the Cell  DOI: 10.1091/mbc.E20-07-0490

Gauthier KD and Rocheleau CE (2021) Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the C. elegans vulval precursor cells. Development doi: 10.1242/dev.194167

Ratemi Z, Kiss RS and Rocheleau CE (2019) C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions. microPublication Biology 10.17912/micropub.biology.000188

Rocheleau CE (2018) C. elegans RAB-35: Dual roles in apoptotic cell clearance. PLoS Genetics 14, e1007534.  (Perspective)

Law F and Rocheleau CE (2017) Vps34 and the Armus/TBC-2 Rab GAPs: Putting the brakes on the endosomal Rab5 and Rab7 GTPases. Cellular Logistics, 7, e1403530. (Review)

Gauthier K and Rocheleau CE (2017) C. elegans vulva induction: an in vivo model to study epidermal growth factor receptor signaling and trafficking. In: Wang Z. (eds) ErbB Receptor Signaling. Methods in Molecular Biology, vol 1652. Humana Press, New York, NY.  (Review)

Law F*, Seo J-H*, Wang Z, DeLeon JL, Bolis Y, Brown A, Zong W-X, Du G and Rocheleau CE (2017) The VPS-34 PI3 kinase negatively regulates RAB-5 during endosome maturation. Journal of Cell Science 130, 2007-2017.

Skorobogata O*, Meng J*, Gauthier K and Rocheleau CE (2016). Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling. Molecular Biology of the Cell, 27, 3771-3779.

Skorobogata O, Escobar-Restrepo JM and Rocheleau CE (2014) An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genetics,10, e1004728.

Rocheleau CE (2012) RNA Interference: Systemic RNAi SIDes with Endosomes. Current Biology, 22, R873-R875.  (Dispatch)

Sun L, Liu O, Desai J, Karbassi F, Sylvain MA, Shi A, Zhou Z, Rocheleau CE, Grant BD (2012) CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. PLoS Genetics, 8, e1002785.

Skorobogata O and Rocheleau CE (2012). RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE, 7, e36489.

Chotard L, Skorobogata O, Sylvain MA, Shrivastava S and Rocheleau CE (2010) TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans. PLoS ONE, 5, e15662.

Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG and Rocheleau CE (2010) TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in C. elegans. Molecular Biology of the Cell, 21, 2285-2296.

Rocheleau CE*, Cullison K*, Huang K, Bernstein Y, Spilker AC and Sundaram MV (2008) The Caenorhabditis elegans ekl (Enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Genetics, 178, 1431-1443.

Rocheleau CE, Ronnlund A, Tuck S and Sundaram MV (2005) Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc. Natl. Acad. Sci. USA, 120, 11757-11762.

Ohmachi M, Rocheleau CE, Church D, Lambie E, Schedl T and Sundaram, M.V. (2002) C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Current Biology, 12, 427-433.

Rocheleau CE*, Howard RM*, Goldman AP, Volk ML, Girard LJ and Sundaram MV (2002) A lin-45 raf enhancer screen identifies eor-1, eor-2, and unusual alleles of Ras pathway genes in Caenorhabditis elegans. Genetics, 161, 121-131.

Bei Y*, Hogan J*, Berkowitz LA, Soto M, Rocheleau CE, Pang KM, Collins J and Mello CC (2002) SRC-1 signaling acts in parallel with Wnt signaling to specify endoderm and to control cleavage orientation in early C. elegans embryos. Developmental Cell, 3, 113-125.

Shin TH*, Yasuda J*, Rocheleau CE*, Lin R, Soto M, Bei Y, Davis RJ and Mello CC (1999) MOM-4, a MAPK kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Molecular Cell, 4, 275-280.

Rocheleau CE*, Yasuda J*, Shin TH*, Lin R, Sawa H, Okano H, Priess JR, Davis RJ and Mello CC (1999) WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell, 97, 717-726.

Rocheleau CE*, Downs WD*, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR and Mello CC (1997) Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell, 90, 707-716.

* equal contributions, lab members