Congrats to Clare and team on their new microPub on AGEF-1 and yolk trafficking!
Congratulations to Clare FitzPatrick and team on their new microPublication (10.17912/micropub.biology.002060) showing that an activating allele in AGEF-1, an Arf GTPase exchange factor, causes yolk trafficking defects in C. elegans embryos.
Interestingly, this allele behaves like a loss-of-function mutation in the context of Arf GTPase effectors that require cycling to regulate trafficking, as is the case with the AP-1 clathrin adaptor complex.
This work suggests embryonic yolk trafficking could be a useful assay for characterizing human ArfGEF1 mutations linked to developmental delay and epilepsy.
